Oxybutynin for Hot Flashes in Women with Breast Cancer
Oxybutynin for Hot Flashes in Women with Breast Cancer
February 25, 2019 (Issue: 1566)
Interim results of a double-blind, placebo-controlled
trial suggest that off-label use of the anticholinergic
drug oxybutynin may reduce the frequency and
severity of hot flashes in women with breast cancer.
Extended-release oral oxybutynin...more
- RA Leon-Ferre et al. A randomized, double-blind, placebo-controlled trial of oxybutynin (Oxy) for hot flashes (HF): ACCRU study SC-1603. Presented at the 2018 San Antonio Breast Cancer Symposium. San Antonio, TX. December 7, 2018. Abstract available at: https://www.abstracts2view.com/ sabcs18/view.php?nu=SABCS18L_1448. Accessed February 14, 2019.
- JA Simon et al. Extended-release oxybutynin therapy for vasomotor symptoms in women: a randomized clinical trial. Menopause 2016; 23:1214.
- Drugs for menopausal symptoms. Med Lett Drugs Ther 2016; 58:142.
- R Ramaswami et al. Venlafaxine in management of hot flashes in women with breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat 2015; 152:231.
- Paroxetine (Brisdelle) for hot flashes. Med Lett Drugs Ther 2013; 55:85.
- JE Desmarais and KJ Looper. Interactions between tamoxifen and antidepressants via cytochrome P450 2D6. J Clin Psychiatry 2009; 70:1688.
- JN Brown and BR Wright. Use of gabapentin in patients experiencing hot flashes. Pharmacotherapy 2009; 29:74.
- CL Loprinzi et al. Phase III, randomized, double-blind, placebo-controlled evaluation of pregabalin for alleviating hot flashes, N07C1. J Clin Oncol 2010; 28:641.
- KJ Pandya et al. Gabapentin for hot flashes in 420 women with breast cancer: a randomised double-blind placebo-controlled trial. Lancet 2005; 366:818.
- CR Chapple et al. Muscarinic receptor subtypes and management of the overactive bladder. Urology 2002; 60 (5 suppl 1):82.
- SL Gray et al. Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med 2015; 175:401.
- Inhibitors and inducers of CYP enzymes and P-glycoprotein. Med Lett Drugs Ther 2017 September 18 (epub). Available at: medicalletter.org/downloads/CYP_PGP_Tables.pdf.
- Approximate WAC. WAC = wholesaler acquisition cost or manufacturer's published price to wholesalers; WAC represents a published catalogue or list price and may not represent an actual transactional price. Source: AnalySource® Monthly. February 5, 2019. Reprinted with permission by First Databank, Inc. All rights reserved. ©2019. www.fdbhealth. com/policies/drug-pricing-policy.
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