Superseded by The Medical Letter "Lipid-Lowering Drugs" - Issue 1659, September 19, 2022
HMG-CoA reductase inhibitors (statins) inhibit the enzyme that catalyzes the rate-limiting step in cholesterol synthesis. The subsequent reduction in hepatic cholesterol leads to increased expression of LDL...

Antiretroviral therapy is recommended for all HIV-infected patients, both to reduce the risk of disease progression and to prevent transmission of the virus to others. Various guidelines for treatment of HIV...

Superseded by The Medical Letter "Drugs for Type 2 Diabetes" - Issue 1663, November 14, 2022
The goal of drug therapy for type 2 diabetes is to achieve and maintain a near-normal A1C concentration without inducing hypoglycemia; the target is generally an A1C of 10,000 patients with type 2...

Superseded by The Medical Letter "Drugs for GERD and Peptic Ulcer Disease" - Issue 1647, April 4, 2022
H2-RECEPTOR ANTAGONISTS (H2RAs) — Currently available H2RAs are listed in Table 1. These drugs inhibit the action of histamine at the H2-receptor of the gastric parietal cell, decreasing basal acid...

Superseded by The Medical Letter "Drugs for Hypertension" - Issue 1703, May 27, 2024
Most recent guidelines recommend a BP goal of 140/90 mm Hg. For patients ≥60 years old without diabetes or chronic kidney disease, one guideline recommends 150/90 mm Hg both as the drug treatment...

Superseded by The Medical Letter "Adult Immunization" - Issue 1661, October 17, 2022
Vaccines recommended for adults residing in the US are reviewed here. Vaccines for travel have been reviewed separately. Eight vaccines are currently recommended by the US Advisory Committee on...