Cariprazine (Vraylar) for Adjunctive Treatment of Depression
Cariprazine (Vraylar) for Adjunctive Treatment of Depression
May 29, 2023 (Issue: 1677)
The FDA has approved the second-generation
antipsychotic drug cariprazine (Vraylar — Abbvie) for
adjunctive treatment of major depressive disorder
(MDD) in adults. Cariprazine was previously approved
for treatment of schizophrenia and bipolar...more
- Cariprazine (Vraylar) for schizophrenia and bipolar I disorder. Med Lett Drugs Ther 2016; 58:51.
- Drugs for depression. Med Lett Drugs Ther 2020; 62:25.
- P Davies et al. Pharmacological interventions for treatment-resistant depression in adults. Cochrane Database Syst Rev 2019; 12:CD010557. doi:10.1002/14651858.cd010557.pub2
- Brexpiprazole (Rexulti) for schizophrenia and depression. Med Lett Drugs Ther 2015; 57:116.
- S Durgam et al. Efficacy and safety of adjunctive cariprazine in inadequate responders to antidepressants: a randomized, double-blind, placebo-controlled study in adult patients with major depressive disorder. J Clin Psychiatry 2016; 77:371. doi:10.4088/jcp.15m10070
- GS Sachs et al. Adjunctive cariprazine for the treatment of patients with major depressive disorder: a randomized, double-blind, placebo-controlled phase 3 study. Am J Psychiatry 2023; 180:241. doi:10.1176/appi.ajp.20220504
- WR Earley et al. Cariprazine augmentation to antidepressant therapy in major depressive disorder: results of a randomized, double-blind, placebo-controlled trial. Psychopharmacol Bull 2018; 48:62.
- M Fava et al. Efficacy of adjunctive low-dose cariprazine in major depressive disorder: a randomized, double-blind, placebo-controlled trial. Int Clin Psychopharmacol 2018; 33:312. doi:10.1097/yic.0000000000000235
- Inhibitors and inducers of CYP enzymes, P-glycoprotein, and other transporters. Med Lett Drugs Ther 2023 January 25 (epub). Available at: medicalletter.org/downloads/CYP_PGP_Tables.pdf.
The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.
Would you like to read the rest of this article? Gain access below.
Subscribe
Subscriptions to
The Medical Letter on Drugs and Therapeutics include:
- Print version published and mailed biweekly (26 issues/year)
- Unlimited online access to current and past issues (1988 - present)
- Mobile App
- FREE online per issue CME/CE
Purchase this article:
Title: Cariprazine (Vraylar) for Adjunctive Treatment of Depression
Article code: 1677c
Gain access through your organization
Ask your librarian to consider an Institutional Subscription to The Medical Letter.
