Matching articles for "Paracetamol"
Acetylcysteine (Cetylev) for Acetaminophen Overdose
The Medical Letter on Drugs and Therapeutics • June 19, 2017; (Issue 1523)
The FDA has approved an effervescent tablet
formulation of acetylcysteine (Cetylev – Arbor) to
prevent or lessen hepatic injury after acetaminophen
overdose. Acetylcysteine has been available for years
in...
The FDA has approved an effervescent tablet
formulation of acetylcysteine (Cetylev – Arbor) to
prevent or lessen hepatic injury after acetaminophen
overdose. Acetylcysteine has been available for years
in an IV solution (Acetadote, and generics) and an oral
solution for the same indication; use of the oral solution
has been limited by its unpleasant odor and taste.
In Brief: Does Acetaminophen Increase Blood Pressure?
The Medical Letter on Drugs and Therapeutics • April 18, 2011; (Issue 1362)
A recent article in Circulation reported that acetaminophen (Tylenol, and others; paracetamol outside the US) increased blood pressure in patients with coronary artery disease. This conclusion was based on a...
A recent article in Circulation reported that acetaminophen (Tylenol, and others; paracetamol outside the US) increased blood pressure in patients with coronary artery disease. This conclusion was based on a randomized, placebo-controlled crossover trial in 33 patients; acetaminophen 1 g three times daily for 2 weeks was associated with statistically significant increases in blood pressure of 2.9 mmHg systolic and 2.2 mmHg diastolic.1
NSAIDs can increase blood pressure; the mechanism is thought to be inhibition of cyclooxygenase leading to decreased renal prostaglandin activity. Acetaminophen also inhibits cyclooxygenase (primarily COX-2) and decreases prostaglandin activity.2
The small increases in blood pressure reported with acetaminophen would probably be inconsequential in low-risk patients, but might be a concern for those with cardiovascular disease. Like most drugs, acetaminophen should be used in the lowest effective doses for the shortest possible time. Mild to moderate pain due to osteoarthritis or headache generally responds to a dose of 650 mg.3
1. I Sudano et al. Acetaminophen increases blood pressure in patients with coronary artery disease. Circulation 2010; 122:1789.
2. B Hinz et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J 2008; 22:383.
3. Drugs for pain. Treat Guidel Med Lett 2010; 8:25.
Download U.S. English
NSAIDs can increase blood pressure; the mechanism is thought to be inhibition of cyclooxygenase leading to decreased renal prostaglandin activity. Acetaminophen also inhibits cyclooxygenase (primarily COX-2) and decreases prostaglandin activity.2
The small increases in blood pressure reported with acetaminophen would probably be inconsequential in low-risk patients, but might be a concern for those with cardiovascular disease. Like most drugs, acetaminophen should be used in the lowest effective doses for the shortest possible time. Mild to moderate pain due to osteoarthritis or headache generally responds to a dose of 650 mg.3
1. I Sudano et al. Acetaminophen increases blood pressure in patients with coronary artery disease. Circulation 2010; 122:1789.
2. B Hinz et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J 2008; 22:383.
3. Drugs for pain. Treat Guidel Med Lett 2010; 8:25.
Download U.S. English
Pharmaceutical Drug Overdose
The Medical Letter on Drugs and Therapeutics • September 1, 2006; (Issue 49)
Every pharmaceutical drug is a dose-dependent poison. This article describes the clinical presentation and treatment of some dangerous overdoses commonly reported in...
Every pharmaceutical drug is a dose-dependent poison. This article describes the clinical presentation and treatment of some dangerous overdoses commonly reported in adults.
Acetylcysteine (Acetadote) for Acetaminophen Overdosage
The Medical Letter on Drugs and Therapeutics • August 15, 2005; (Issue 1215)
Acetaminophen (paracetamol; Tylenol, and others) taken in overdosage can cause severe hepatic injury and death. Acetaminophen poisoning is treated with (N-)acetylcysteine. Available for many years in the US as...
Acetaminophen (paracetamol; Tylenol, and others) taken in overdosage can cause severe hepatic injury and death. Acetaminophen poisoning is treated with (N-)acetylcysteine. Available for many years in the US as a solution for inhalation therapy (Mucomyst, and others), it subsequently became available for oral use and was recently marketed in the US for intravenous (IV) use as Acetadote (Cumberland).